Multimedia in the informed consent process for endoscopic sinus surgery: A randomized control trial.

Objectives/hypothesis: To determine patient recall of specific risks associated with endoscopic sinus surgery and whether an adjunct multimedia education module is an effective patient tool in enhancing the standard informed consent process.

Study Design: Prospective, randomized, controlled trial.

Methods: Fifty consecutive adult patients scheduled for endoscopic sinus surgery at a rhinology clinic of a tertiary care hospital were recruited for this study.

Carcinoma of the larynx, metastatic to illeum, presents as ruptured appendicitis: case report and literature review.

Objectives: Metastasis of laryngeal squamous cell carcinoma (SCC) to the intra-abdominal gastrointestinal tract is exceedingly rare. The objectives of this case report are to describe a case involving a perforated metastasis of a laryngeal SCC to the ileum and to review the literature pertaining to other similar cases.

Methods: A review of patient's chart and a review of the English literature involving malignant SCC of the larynx with metastasis to the small bowel.

Preoperative concerns of patients undergoing endoscopic sinus surgery.

Background: Patient-centered care is recognized as being fundamental to successful medical practice. The effectiveness of patient-centered care has classically been measured by posttreatment outcomes, such as patient compliance and psychosocial responses. Systematic assessment of patient concerns prior to treatment has been limited, to date.

An endonasal approach to the resection of a papillary seromucinous adenocarcinoma of the eustacian tube.

Objectives: Papillary seromucinous adenocarcinoma of the sinonasal tract is exceedingly rare. The objectives of this case report are to describe a case of papillary seromucinous adenocarcinoma presenting in the nasopharynx and to review the literature pertaining to other similar cases.

Methods: A review of the patient's chart and a review of the English literature were conducted.

Does HPV type affect outcome in oropharyngeal cancer?

Background: An epidemic of human papillomavirus (HPV)-related oropharyngeal squamous cell cancer (OPSCC) has been reported worldwide largely due to oral infection with HPV type-16, which is responsible for approximately 90% of HPV-positive cases. The purpose of this study was to determine the rate of HPV-positive oropharyngeal cancer in Southwestern Ontario, Canada.

Methods: A retrospective search identified ninety-five patients diagnosed with OPSCC.

Development of a transoral robotic surgery program in Canada.

Due to significant differences in healthcare structure between the United States and Canada, there are unique barriers to adopting new medical technology in Canada. In this article, we describe our experience developing a transoral robotic surgery (TORS) program at Western University. Specifically, we outline the steps that were necessary to obtain institutional and multidisciplinary team approval, financial support, as well as surgeon and allied healthcare personnel training.

Transoral robotic total laryngectomy: report of 3 cases.

Background: Because of the significant toxicity of chemoradiation regimens, there has been a resurgence of interest in the primary surgical management of head and neck cancer and, in particular, the use of minimally invasive surgery. One such technique is transoral robotic surgery (TORS). We aim to discuss the potential role of TORS in patients requiring total laryngectomy (TL).

A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing.

Background. Next-generation sequencing of cancers has identified important therapeutic targets and biomarkers. The goal of this pilot study was to compare the genetic changes in a human papillomavirus- (HPV-)positive and an HPV-negative head and neck tumor.

A novel tool for the objective measurement of neck fibrosis: validation in clinical practice.

Background: Radiotherapy is commonly used to treat neoplasms of the head and neck, and fibrosis is a known side effect. The Cutometer is a device that quantifies properties of the skin. The goal of the study was to validate the Cutometer in normal neck tissues and then quantify fibrosis in radiated necks.

Frequent mutations in TP53 and CDKN2A found by next-generation sequencing of head and neck cancer cell lines.

Objective: To conduct high-throughput mutational analysis in 6 commonly used head and neck cancer cell lines. Comprehensive mutation analysis of primary head and neck squamous cell carcinoma (HNSCC) tumors has recently been reported, and mutations in the NOTCH receptors, TP53 and CDKN2A, were key findings. Established cell lines are valuable tools to study cancer in vitro.

The role of transoral robotic surgery in the management of oropharyngeal cancer: a review of the literature.

Background. Transoral robotic surgery (TORS) is an emerging treatment option for the treatment of head and neck malignancies, particularly for oropharyngeal squamous cell carcinoma (OPSCC). Preliminary studies have demonstrated excellent oncologic and functional outcomes that have led to a resurgence of interest in the primary surgical management of OPSCC.

Ki-67 expression predicts radiotherapy failure in early glottic cancer.

Background: Early-stage laryngeal squamous cell carcinoma is managed with radiotherapy or endoscopic surgery. Although cure rates are high, radiation failures often require total laryngectomy for salvage. Biomarkers that can predict tumour radioresistance may be useful in modifying the treatment approach for individual patients.

The Western Surgical Concern Inventory-Thyroid: development and initial validation.

Objective: Patients considering surgery face many uncertainties and concerns. This investigation sought to develop an objective assessment tool for characterizing the areas of greatest concern among those considering thyroidectomy.

Study Design: Prospective cohort design.

Discrepancy between ultrasound and final pathologic measurements in thyroid cancer.

Background: The size of the malignancy in well-differentiated thyroid carcinoma (WDTC) is an important factor in patient risk stratification. Final pathologic measurements are currently used for treatment decisions. Measurements are made by both ultrasonography and on final pathology and should, theoretically, agree with each other.

Prospective evaluation of preoperative concern among patients considering endoscopic sinus surgery: initial validation.

Background: Patients considering surgery face many uncertainties and concerns. This investigation aimed to develop an objective assessment tool for characterizing the areas of greatest concern among patients considering endoscopic sinus surgery (ESS).

Methods: As part of validating a clinical measure concerning perioperative concerns, patients presenting with chronic rhinosinusitis with or without nasal polyposis were voluntarily recruited.

A descriptive analysis of the relationship between quality of life and distress in individuals with head and neck cancer.

Purpose: Both short- and long-term outcomes for individuals with head and neck cancer (HNCa) may be influenced by multiple factors. Identification of distress in those with HNCa may provide a critical dimension that influences quality of life (QoL). Consequently, this investigation assessed distress and QoL in those with HNCa.

Detection of circulating tumor cells in advanced head and neck cancer using the CellSearch system.

Background: Early detection of circulating tumor cells (CTCs) offers the possibility of improved outcome for patients with head and neck squamous cell cancer (HNSCC).

Methods: Patients with advanced-stage HNSCC (stage III/IV) were tested for CTCs using the CellSearch system (a registered trade name), which has been approved by the U.S.

Comparison of endoscopic laser resection versus radiation therapy for the treatment of early glottic carcinoma.

Objective: Radiation therapy (RT) and transoral laser microsurgery (TLM) are established treatments for early glottic squamous cell carcinoma (SCC). Similar oncologic outcomes have been reported with both modalities, leading physicians to consider other factors when making clinical recommendations. One such factor is voice-related quality of life.

Ketorolac in thyroid surgery: quantifying the risk of hematoma.

Objective: Hematoma is a potentially life-threatening complication of thyroid surgery. Ketorolac is a nonsteroidal anti-inflammatory drug with known antiplatelet activity that is used for analgesia. The goal of this study was to determine the risk of hematoma in patients who received ketorolac in thyroid surgery.

What are thyroidectomy patients really concerned about?

Objective: To better appreciate perioperative concerns affecting patients considering thyroidectomy and to understand how they may vary according to patient characteristics.

Study Design: Cross-sectional analysis.

Setting: Tertiary referral center.

The N3 neck: outcomes following primary chemoradiotherapy.

Objective: To study the treatment outcomes of N3 neck disease following primary chemoradiotherapy.

Design: Retrospective cohort.

Setting: Tertiary care centre.

Voice-related quality of life (V-RQOL) outcomes in laryngectomees.

Background: Laryngeal cancer has a significant impact on patients. This study compared the Voice-Related Quality of Life (V-RQOL) outcomes specific to 3 different postlaryngectomy voice rehabilitation methods.

Methods: We conducted a retrospective review of 75 patients with laryngectomy from our V-RQOL questionnaire database.