Cardiovascular disease risk is associated with middle cerebral artery blood flow velocity in older adults.

Purpose: The aim of this study was to evaluate the of cardiovascular disease (CVD) on middle cerebral blood flow velocity (MCAv) at rest and during exercise. A secondary aim was to explore the relationship between MCAv and 1) the presence of white matter lesions and 2) cognitive function.

Methods: We recruited individuals who were cognitively normal older adults.

Vascular Health is Associated with Amyloid-β in Cognitively Normal Older Adults.

Background: Vascular health is closely related to Alzheimer's disease (AD). Vascular function measured by flow mediated dilation (FMD) or pulsatility index (PI) can be used as marker of peripheral and central vascular health but is poorly characterized in those at risk for AD.

Objective: To assess the relationship of peripheral and central vascular function with amyloid-β (Aβ) and white matter lesion burden among cognitively normal older adults.