Publications by authors named "Jason Chua Min-Wen"
During ageing, adult stem cells' regenerative properties decline, as they undergo replicative senescence and lose both their proliferative and differentiation capacities. In contrast, embryonic and foetal progenitors typically possess heightened proliferative capacities and manifest a more robust regenerative response upon injury and transplantation, despite undergoing many rounds of mitosis. How embryonic and foetal progenitors delay senescence and maintain their proliferative and differentiation capacities after numerous rounds of mitosis, remains unknown.
View Article and Find Full Text PDFMolecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy.
Adv Protein Chem Struct Biol
October 2017
Cancer is an extremely complex disease comprising of a multitude of characteristic hallmarks that continue to evolve with time. At the genomic level, random mutations leading to deregulation of diverse oncogenic signal transduction cascades and polymorphisms coupled with environmental as well as life style-related factors are major causative agent contributing to chemoresistance and the failure of conventional therapies as well as molecular targeted agents. Hence, there is an urgent need to identify novel alternative therapies based on alternative medicines to combat this dreaded disease.
View Article and Find Full Text PDFArticle Synopsis
- Cachexia is a severe muscle-wasting syndrome often seen in advanced cancer patients, affecting 80% of them and significantly contributing to morbidity and mortality.
- Research indicates that cachectic cancer cells secrete inflammatory factors that enhance fatty acid metabolism, activating stress responses in skeletal muscles before muscle atrophy is evident.
- Targeting fatty acid-induced oxidative stress may be a potential way to combat cancer-induced cachexia, as blocking this process has shown benefits in restoring muscle growth and improving overall body weight.
Article Synopsis
- - Mitochondria are essential for energy production and regulate reactive oxygen species (ROS) levels, with their own DNA that influences cellular metabolism and stem cell behavior during regeneration and aging.
- - Stem cell factors and nutrient-sensitive signaling pathways interact with mitochondrial processes to balance self-renewal and differentiation, impacting longevity and tissue homeostasis as organisms age.
- - Targeting mitochondrial repair in stem cells may offer a promising approach to address aging-related degenerative diseases, given the significant role mitochondria play in cellular health and longevity.