Myasthenia gravis exacerbation in association with antibody overshoot following plasmapheresis.

Introduction/aim: Antibody overshoot following therapeutic plasmapheresis (PLEX) is defined by subsequent increase in antibody to levels exceeding those prior to removal. It has been infrequently described in the past, and its influence on the clinical course of myasthenia gravis (MG) remains unclear.

Methods: This was a retrospective analysis of five patients with generalized MG treated with PLEX.

Prognosis Following Discontinuation of OnabotulinumA Therapy in "Super-responding" Chronic Migraine Patients.

Objective: To determine whether the successful treatment of chronic migraine (CM) with onabotulinumA (BotoxA) may be followed by a continued respite from headache once therapy has been discontinued.

Background: The optimal duration of prophylactic therapy for migraine generally and for CM treated with BotoxA specifically is unknown.

Methods: We conducted a prospective cohort study evaluating a series of patients with CM at a university-affiliated headache subspecialty clinic in Reno, Nevada, all of whom were treated according to a uniform protocol involving serial injections of BotoxA.

Breast Lesions Detected via Molecular Breast Imaging: Physiological Parameters Affecting Interpretation.

Rationale And Objectives: To evaluate correlations between molecular breast imaging (MBI) descriptor characteristics and positive predictive value (PPV) in detecting breast cancer.

Materials And Methods: A retrospective review was performed on 193 suspicious findings from 153 women (31-81 years) with positive MBI examinations. We assessed associations between (i) lesion pattern (mass vs.

Air quality modeling of hazardous pollutants: current status and future directions.

The current requirements and status of air quality modeling of hazardous pollutants are reviewed. Many applications require the ability to predict the local impacts from industrial sources or large roadways as needed for community health characterization and evaluating environmental justice concerns. Such local-scale modeling assessments can be performed by using Gaussian dispersion models.