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Publications by authors named "Jason Breed"

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Synopsis of recent research by authors named "Jason Breed"

  • - Jason Breed's recent research focuses on structural determination and drug design for small therapeutic proteins and inhibitors against critical oncogenic targets, especially in relation to KRAS mutations and estrogen receptors.
  • - His work has led to the identification of several potent compounds, such as AZD4747 and AZD4625, which target mutant KRAS for cancer treatment, showcasing specific mechanisms for CNS penetration and allosteric inhibition.
  • - Breed's use of innovative techniques, such as cryoelectron microscopy and structure-based drug design, has enabled advancement in understanding protein structures at high resolutions and optimizing pharmacokinetics for clinical candidates in oncology.

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