Insult to the central nervous system (CNS) results in an early inflammatory response, which can be exploited as an initial indicator of neurological dysfunction. Nanoparticle drug delivery systems provide a mechanism to increase the uptake of drugs into specific cell types in the CNS such as microglia, the resident macrophage responsible for innate immune response. In this study, we developed two nanoparticle-based carriers as potential theranostic systems for drug delivery to microglial cells.
View Article and Find Full Text PDFElectrokinetic phenomena such as dielectrophoresis and electrothermal fluid flow are used to increase the rate of mass transfer of silver and platinum nanoparticles and improve their stochastic electrochemical detection. These phenomena are induced by applying a high frequency alternating current (ac) waveform between a counter electrode and a working disk microelectrode. By recording chronoamperograms at room temperature and various ac powers, it is shown that the ac heating leads to an increase in the collision frequency of studied nanoparticles with working electrode surface by a factor of ∼10-10 as well as the increase in the magnitude of the measured faradaic response.
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