Publications by authors named "Jason B Viana"
Article Synopsis
- The study looked at how stress-induced binge-eating in rats, particularly those with a history of caloric restriction, responded to fluoxetine treatment.
- Young female rats were categorized based on their diet and stress levels, treated with fluoxetine, and then analyzed for brain chemicals related to feeding and reward.
- Results showed that fluoxetine helped reduce binge-eating in caloric-restricted rats, but also indicated that their brain serotonin and dopamine interactions had changed, suggesting implications for understanding diet, reward, and mood.
The authors developed an animal model of binge eating where history of caloric restriction with footshock stress (R + S) causes rats to consume twice the normal amount of palatable food. The authors tested the hypothesis that binge eating is mediated by changes in opioid control of feeding by comparing rats' anorectic and orexigenic responses to naloxone and butorphanol, respectively, and by testing the ability of butorphanol to elicit binge eating of chow when palatable food was absent. Mu/kappa opioid-receptor blockade and activation had exaggerated responses in the R + S rats with naloxone suppressing binge eating to control levels, and although butorphanol did not trigger chow binge eating, it enhanced binge eating of palatable food.
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