Publications by authors named "Jason B Crawford"
Article Synopsis
- - The study created new oral drugs that effectively block the CXCR4 chemokine receptor, which HIV-1 uses to enter cells, enhancing potential treatments for HIV-1 infections.
- - A specific compound, AMD070, was identified as a strong CXCR4 antagonist with low toxicity and effective in inhibiting T-tropic HIV-1 replication in lab tests.
- - The drug showed good absorption when given orally in tests on rats and dogs, marking it as the first small molecule CXCR4 antagonist suitable for treating HIV-1.
A spontaneous dynamic kinetic resolution of 8-amino-5,6,7,8-tetrahydroquinoline 1 was observed in the presence of Candida antarctica Lipase B, in which a >60% yield of (R)-acetamide [(R)-2] was isolated from the racemic amine. The spontaneous formation of ketone 3, followed by a condensation/hydrolysis sequence with the remaining (S)-amine 1, via enamine 4, provides the necessary racemization pathway.
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