Publications by authors named "Jason A Cole"

Article Synopsis
  • Hyperoxaluria after Roux-en-Y gastric bypass (RYGB) was studied to see if it correlates with fat malabsorption in severely obese patients.
  • Before RYGB, patients had mild to moderate steatorrhea but no correlation between fecal fat and urine oxalate excretion was found, while after RYGB, steatorrhea and urine oxalate increased significantly with a positive correlation.
  • The study suggests that while hyperoxaluria was common pre-bypass, it was likely not due to excess unabsorbed fats, but possibly driven by other factors like obesity or metabolic syndrome, with a more direct correlation observed post-surgery.
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We re-evaluated the old hypothesis that gastritis-induced achlorhydria is a cause of iron deficiency anemia (IDA) in humans. First, we analyzed the currently available research on the association between achlorhydria and IDA. When gastric acid secretion was measured after maximal stimulation, the frequency of achlorhydria (or severe hypochlorhydria) was 44% in patients with idiopathic IDA and 1.

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The practical diagnostic value of fecal analysis in the evaluation of patients with chronic nonbloody diarrhea is controversial. It is possible that variations in its value depend on how it is done and how the results are interpreted rather than on its intrinsic value. In the authors' city, stool analysis has been made easily accessible, with a commitment to quality assurance and interpretation.

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