Publications by authors named "Jasmine M Madsen"
Background: Glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment reduces cardiovascular events in type 2 diabetes. Yet, the impact of GLP-1RA treatment before ST-segment elevation myocardial infarction (STEMI) on long-term prognosis in patients with type 2 diabetes remains unclear. In patients with STEMI and type 2 diabetes, we aimed to investigate the association between long-term prognosis and GLP-1RA treatment before STEMI.
View Article and Find Full Text PDFImportance: In patients with ST-segment elevation myocardial infarction (STEMI), acute inflammation is related to the extent of myocardial damage and may increase infarct size. Thus, administration of pulse-dose glucocorticoid in the very early phase of infarction may reduce infarct size.
Objective: To determine the cardioprotective effect of prehospital pulse-dose glucocorticoid in patients with STEMI.
Background: Intracoronary physiology, particularly fractional flow reserve (FFR), has been used as a guide for revascularization for patients with coronary artery disease (CAD). The optimal treatment in the physiological grey-zone area has been unclear and remains subject to ongoing debate.
Methods: We conducted a systematic review of randomized controlled trials and observational studies comparing the prognostic effect of percutaneous coronary revascularization (PCI) and optimal medical therapy (OMT) in patients with CAD.
Aims: Remnant cholesterol (RC) is the cholesterol content within triglyceride-rich lipoproteins. It promotes atherosclerotic cardiovascular disease beyond LDL cholesterol (LDL-C). The prognostic role of RC in patients with ST-segment elevation myocardial infarction (STEMI) is unknown.
View Article and Find Full Text PDFBackground: Inflammation in ST-segment elevation myocardial infarction (STEMI) is an important contributor to both acute myocardial ischemia and reperfusion injury after primary percutaneous coronary intervention (PCI). Methylprednisolone is a glucocorticoid with potent anti-inflammatory properties with an acute effect and is used as an effective and safe treatment of a wide range of acute diseases. The trial aims to investigate the cardioprotective effects of pulse-dose methylprednisolone administered in the pre-hospital setting in patients with STEMI transferred for primary PCI.
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- This study looked at how permanent damage to the right ventricle (RV) affects patients who had a heart attack called inferior STEMI, especially when the blockage is in the right coronary artery (RCA).
- Researchers used cardiac magnetic resonance imaging to assess the heart function of 291 patients shortly after the event and three months later, finding that 20% had permanent RV damage which negatively impacted their heart function.
- While this RV damage was linked to larger areas of heart tissue injury, it didn't predict how well the left ventricle (LV) would function overall, suggesting that RV health plays a role in predicting damage but not in predicting LV performance.
Article Synopsis
- The study focused on patients with ST-segment elevation myocardial infarction (STEMI) and explored the outcomes of those who underwent percutaneous coronary intervention (PCI) without stenting compared to those who received immediate stenting.
- Results showed that in a follow-up period of 3.4 years, patients who did not receive stenting had similar rates of major adverse events, including mortality and recurrent myocardial infarctions, as those who underwent immediate stenting.
- The findings suggest that in cases where there is no significant residual stenosis and stable blood flow post-PCI, stenting might be unnecessary, potentially leading to less invasive treatment options for STEMI patients.
Article Synopsis
- Ischemic postconditioning (iPOST) in patients with STEMI showed mixed results in reducing reperfusion injury and its long-term benefits were unclear, particularly in those not receiving thrombectomy.
- In a study involving 1,234 patients, iPOST significantly lowered the rates of cardiovascular mortality and heart failure hospitalizations in those who did not undergo thrombectomy, compared to conventional PCI treatment.
- However, iPOST did not demonstrate any significant advantage in patients who were treated with thrombectomy, suggesting its benefits may vary based on the treatment method used.
Impella mechanical circulatory support: does it take of the load or create a catastrophe?
Eur Heart J Acute Cardiovasc Care
December 2021
Background: New-onset atrial fibrillation (NEW-AF) following ST-segment elevation myocardial infarction (STEMI) is a common complication, but the true prognostic impact of NEW-AF is unknown. Additionally, the optimal treatment of NEW-AF among patients with STEMI is warranted.
Methods: A large cohort of consecutive patients with STEMI treated with percutaneous coronary intervention were identified using the Eastern Danish Heart Registry from 1999-2016.
Selective serotonin reuptake inhibitors (SSRIs) are the first-line drugs in the treatment of depression. Investigations of the effects of SSRIs in healthy individuals is a useful model to understand the mechanisms of SSRI action and potentially the underlying pathophysiology of depression. We conducted an updated systematic review of all randomized multiple-dose, placebo-controlled trials on the effect of intervention with SSRI for ≥ 7 days in healthy nonpsychiatric subjects.
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