Publications by authors named "Jasmine Dhatt"
Article Synopsis
- Colorectal cancer (CRC) can be influenced by intestinal microbiota, specifically through short chain fatty acids (SCFAs) that impact immune responses; however, the exact mechanisms are not fully understood.
- Research using various CRC models revealed that SCFA treatment enhances the activation of CD8+ T cells, particularly in CRCs with microsatellite instability (MSI), which are more responsive to SCFAs than chromosomally unstable (CIN) types.
- The observed increased activation of CD8+ T cells in MSI CRCs is linked to SCFA-induced genetic changes and a positive feedback loop between CRC cells and T cells, suggesting that SCFAs contribute to the immunogenicity and better prognosis of
