Publications by authors named "Jasmine Cicek Leifing Atay"
Article Synopsis
- Renal fibrosis is a key factor that worsens chronic kidney disease (CKD), resulting from excess extracellular matrix, and current treatments largely only target underlying conditions rather than the fibrosis itself.
- This study investigates the use of preconditioned human adipose-derived mesenchymal stromal cells (Pr-MSCs) and their extracellular vesicles (EVs) for their anti-fibrotic potential, finding that local delivery of Pr-MSCs significantly reduced fibrosis markers and improved anti-inflammatory responses in kidney cells.
- The results indicate that local administration of Pr-MSCs is more effective than systemic delivery, and the anti-fibrotic effects are likely due to soluble factors produced by Pr-MSCs, rather than the
Mesenchymal stromal/stem cell (MSC) therapy has been thoroughly tested in preclinical animal models and holds great promise for the treatment of kidney diseases. It is becoming increasingly evident that the efficacy of MSC therapy is dependent on several factors including dosage, the tissue source of MSCs, the route of delivery and timing of administration. In a time where MSC therapy is moving from preclinical research to clinically therapeutic use, the importance of choice of delivery method, modality, and administration route increases.
View Article and Find Full Text PDF