Publications by authors named "Jasmine C Dowell"
Article Synopsis
- The study investigates the causes and circumstances of death in pediatric acute respiratory distress syndrome (ARDS), hypothesizing that nonpulmonary factors, rather than hypoxemia, lead to most fatalities.
- Among 798 cases analyzed, 153 children died, with a median time of 6 days until death; those who died early often suffered from severe illness and neurologic issues, while later deaths were associated with multisystem organ failure.
- Withdrawal of therapy was the main cause of death across timeframes, with refractory hypoxemia contributing to only 20% of the deaths, highlighting the need for a broader understanding of mortality factors in pediatric ARDS.
Objectives: Literature regarding appropriate use of inhaled nitric oxide for pediatric acute respiratory distress syndrome is sparse. This study aims to determine if positive response to inhaled nitric oxide is associated with decreased mortality and duration of mechanical ventilation in pediatric acute respiratory distress syndrome.
Design: Retrospective cohort study.
Protein kinase C (PKC)-mediated phosphorylation of cardiac myofilament (MF) proteins has been shown to depress the actomyosin interaction and may be important during heart failure. Biochemical studies indicate that phosphorylation of Ser(43) and Ser(45) of cardiac troponin I (cTnI) plays a substantial role in the PKC-mediated depression. We studied intact and detergent-extracted papillary muscles from nontransgenic (NTG) and transgenic (TG) mouse hearts that express a mutant cTnI (Ser43Ala, Ser45Ala) that lacks specific PKC-dependent phosphorylation sites.
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