The chemical mechanism of action of glucose oxidase from Aspergillus niger.

Glucose oxidase from Aspergillus niger (EC 1.1.3.

Bioorganic mechanisms of the formation of free radicals catalyzed by glucose oxidase.

In this communication, we have described the activation of several xenobiotics by glucose oxidase from Aspergillus niger. The following compounds are readily reduced by d-glucose, in the presence of glucose oxidase: p-nitroso-N,N-dimethylaniline, methyl-1,4-benzoquinone, and 7,7,8,8-tetracyano-quinodimethane. In each case, the products of enzymatic reduction undergo a dismutation reaction with the parent compound and thus afford the formation of free radicals.