Publications by authors named "Jasmina Hoffe"
Hypertension
December 2024
Article Synopsis
- High salt (HS) intake can worsen immune responses and contribute to the development of hypertensive vascular diseases, particularly after exposure to Ang II, a hormone that raises blood pressure.
- In experiments with mice, a short period of HS consumption led to increased inflammation and a higher occurrence of severe vascular issues when combined with Ang II infusion, despite no blood pressure differences between groups.
- The study concludes that transient HS intake triggers a mild immune response that becomes problematic when followed by Ang II exposure, suggesting that HS acts as a precursor to more significant hypertension-related health risks.
Circulation
September 2024
Article Synopsis
- The study investigates how aortic valve stenosis (AS) impacts endothelial function independently of usual cardiovascular risk factors in both mice and human cohorts.
- The researchers found that AS led to systemic endothelial dysfunction characterized by increased extracellular hemoglobin (eHb), nitric oxide consumption, and mechanical stress in the aorta.
- Treatment methods, including the use of haptoglobin and transcatheter aortic valve replacement, were effective in restoring endothelial function in both experimental and clinical settings.
Basic Res Cardiol
May 2022
Article Synopsis
- - The text discusses a study on aortic valve stenosis (AS), a common heart valve disease, focusing on a newly developed mouse model that mimics human AS characteristics and allows for advanced imaging techniques to assess disease progression.
- - Researchers induced AS in mice and used high-resolution MRI to analyze changes in the heart and aorta, finding significant structural and functional alterations, such as valve thickening, turbulent blood flow, and mild heart muscle growth, while global heart function remained relatively normal.
- - The study revealed early signs of myocardial tissue remodeling and coronary flow issues before overt heart failure, identifying critical points in AS progression that could help guide future treatment strategies.
