Publications by authors named "Jasmin P Htun"
Background: Adults <55 years of age comprise a quarter of all acute coronary syndromes (ACS) hospitalisations. There is a paucity of data characterising this group, particularly sex differences. This study aimed to compare the clinical and risk profile of patients with ACS aged <55 years with older counterparts, and measure short-term outcomes by age and sex.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on using genomic sequencing to uncover novel genetic variants in congenital heart disease (CHD) patients, specifically a variant of uncertain significance (VUS) in the GATA4 gene, which requires functional analysis to determine its impact on disease.
- - Researchers used CRISPR gene editing on induced pluripotent stem cells (iPSCs) to create a model for studying the effects of the GATA4 VUS, comparing the genetic variant cells with healthy controls through cardiomyocyte differentiation experiments.
- - Results showed that the variant cardiomyocytes exhibited abnormal gene expression related to cardiac function and altered electrical activity, supporting the idea that the VUS could have damaging effects, while also demonstrating an effective method for assessing