Publications by authors named "Jasmin Ortolan"
Article Synopsis
- Transplanted mesenchymal stromal/stem cells (MSC) were found to improve conditions in a mouse model of multiple sclerosis (MS) by reducing inflammation and demyelination through interactions with immune and neural cells.
- MSC were shown to prevent harmful changes in astrocytes (a type of brain cell) related to MS, reducing inflammatory cytokines and promoting a healthier environment for recovery.
- The study suggests that MSC may enhance the ability of astrocytes to adopt stem cell-like properties, which could support healing and protection in the brain following injury.
With evidence supporting the prion-like spreading of extracellular tau as a mechanism for the initiation and progression of Alzheimer's disease (AD), immunotherapy has emerged as a potential disease-modifying strategy to target tau. Many studies have proven effective to clear pathological tau species in animal models of AD, and several clinical trials using conventional immunotherapy with anti-tau native antibodies are currently active. We have previously generated a vectorized scFv derived from the conformation-dependent anti-tau antibody MC1, scFvMC1, and demonstrated that its intracranial injection was able to prevent tau pathology in adult tau mice.
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