High-dose chemotherapy for children and young adults with stage IV rhabdomyosarcoma.

Background: Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. Prognosis for patients with metastatic disease has not improved significantly in the past decades. High-dose chemotherapy (HDC) seems to be an attractive option to treat minimal residual disease in metastatic rhabdomyosarcoma patients.

Prevalence of rib anomalies in normal Caucasian children and childhood cancer patients.

Purpose: To evaluate the prevalence of abnormalities of rib development in normal Caucasian children and patients with childhood cancer.

Materials And Methods: Chest radiographs of 881 Caucasian pediatric controls and 906 childhood cancer patients were reviewed, and independently scored by four blinded observers, using strict definitions. Prevalences of 6 major rib anomaly categories in controls were compared to their prevalence in the total group of childhood cancer patients, and the 12 individual larger tumor groups using Chi-square tests.