Publications by authors named "Jasbir Bisht"

Article Synopsis
  • Serotonin, a neurotransmitter produced from tryptophan, plays multiple roles in regulating bodily functions like sleep, appetite, and anxiety, and is linked to Alzheimer's disease and various psychiatric disorders.
  • It helps neurons to develop and adapt, and recent studies show that serotonin is also found in immune cells, influencing intracellular processes through protein modifications.
  • The article reviews the history and recent findings on serotonin's impact on depression, aging, and neurological diseases, focusing on its biological functions and potential therapeutic strategies.
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Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRD) are the primary public health concerns in the United States and around the globe. AD/ADRD are irreversible mental illnesses that primarily impair memory and thought processes and may lead to cognitive decline among older individuals. The prevalence of AD/ADRD is higher in Native Americans, followed by African Americans and Hispanics.

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Diabetes is an age-related chronic health condition and a major public health concern. Diabetes is one of the significant causes of morbidity and mortality and a major contributing factor to dementia. Recent research reveals that Hispanic Americans are at an increased risk of chronic conditions such as diabetes, dementia, and obesity.

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Cancer is a public health concern and causes more than 8 million deaths annually. Cancer triggers include population growth, aging, and variations in the prevalence and distribution of the critical risk factors for cancer. Multiple hallmarks are involved in cancer, including cell proliferation, evading growth suppressors, activating invasion and metastasis, resisting cell death, enabling replicative immortality, reprogramming energy metabolism, and evading immune destruction.

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Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta (Aβ) deposits and neurofibrillary tangles are the major pathological features in an Alzheimer's brain. These proteins are highly expressed in nerve cells and found in most tissues.

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