Publications by authors named "Jarrod Wesley Barnes"
Article Synopsis
- Idiopathic pulmonary fibrosis (IPF) is a serious lung disease marked by excessive collagen buildup, leading to respiratory failure, with no existing treatments to effectively reverse fibrosis despite some therapies that slow progression.* -
- The study used single-cell RNA sequencing and various models to investigate the role of O-linked N-Acetylglucosamine (O-GlcNAc) transferase (OGT) in regulating collagen production and fibrosis in IPF, finding it elevated in IPF patients and crucial in modulating Smad3 activation.* -
- Results suggest that inhibiting OGT can reduce collagen accumulation in IPF, making it a promising target for therapies aimed at both fibrosis resolution and other related diseases characterized by excessive extracellular
Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease of complex etiology. Cases of PAH that do not receive therapy after diagnosis have a low survival rate. Multiple reports have shown that idiopathic PAH, or IPAH, is associated with metabolic dysregulation including altered bioavailability of nitric oxide (NO) and dysregulated glucose metabolism.
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