Publications by authors named "Jarrod Stein"
Background: New ultrasensitive methods for detecting residual disease after surgery are needed in human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV+OPSCC).
Methods: To determine whether the clearance kinetics of circulating tumor human papillomavirus DNA (ctHPVDNA) is associated with postoperative disease status, a prospective observational study was conducted in 33 patients with HPV+OPSCC undergoing surgery. Blood was collected before surgery, postoperative days 1 (POD 1), 7, and 30 and with follow-up.
Article Synopsis
- HPV+HNSCC is a rising HPV-related cancer in the U.S., and traditional diagnostic methods like tissue biopsies and p16 IHC are invasive and vary in sensitivity.* -
- A study involving 140 subjects found that a noninvasive method using circulating tumor HPV DNA (ctHPVDNA), along with imaging and physical exams, showcased a sensitivity of 95.1% and specificity of 98.6%, outperforming standard methods.* -
- This noninvasive approach not only improved diagnostic accuracy but also reduced costs by 36-38% and shortened the diagnostic time by 26 days, indicating it could be a more effective alternative in the future.*