Diffusion-weighted magnetic resonance imaging of the prostate: improved robustness with stretched exponential modeling.

Purpose: This study aimed to compare the intraclass correlation coefficients of parameters estimated with stretched exponential and biexponential diffusion models of in vivo diffusion-weighted magnetic resonance imaging (MRI) of the prostate.

Methods: After the institutional review board issued a waiver of informed consent for this Health Insurance Portability and Accountability Act-compliant study, 25 patients with biopsy-proven prostate cancer underwent 3T endorectal MRI and diffusion-weighted MRI of the prostate at 10 b values (0, 45, 75, 105, 150, 225, 300, 600, 900, and 1200 s/mm). The full set of b values was collected twice within a single acquisition.