Binding of FliW Adjacent to the CsrA RNA-Binding Pockets Modulates CsrA Regulatory Activity.

CsrA is an mRNA-binding, post-transcriptional regulator that controls many metabolic- and virulence-related characteristics of this important pathogen. In contrast to CsrA, whose activity is modulated by binding to small non-coding RNAs (sRNAs), CsrA activity is controlled by binding to the CsrA antagonist FliW. In this study, we identified the FliW binding site on CsrA.