Evidence that transverse variability of critical current density can greatly mitigate screening current stress in high field REBCO magnets.

Plastic damage of REBCO (REBaCuO, where RE=rare earth) coated conductors by screening current stress (SCS) is a significant concern for ultra-high-field superconducting magnets. Indeed, the third Little Big Coil (LBC3), a REBCO magnet that generated a record, high field of 45.5 T, showed wavy plastic damage produced by excess SCS in all pancakes except two made with single-slit conductors having their slit edges pointing inward towards the magnet center.

AOTMiT reimbursement recommendations compared to other HTA agencies.

Our objective was to compare AOTMiT (Polish: Agencja Oceny Technologii Medycznych i Taryfikacji) recommendations to other HTA (Health Technology Assessment) agencies for newly registered drugs and new registration indications issued by the European Medicines Agency between 2014 and 2019. The study aims to assess the consistency and justifications of AOTMiT recommendations compared to that of other HTA agencies in 11 countries. A total of 2496 reimbursement recommendations published by 12 HTA agencies for 464 medicinal products and 525 indications were analyzed.

The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma Multiforme.

Glioblastoma multiforme (GBM) represents the most common and aggressive malignant form of brain tumour in adults and is characterized by an extremely poor prognosis with dismal survival rates. Currently, expanding concepts concerning the pathophysiology of GBM are inextricably linked with neuroinflammatory phenomena. On account of this fact, the identification of novel pathomechanisms targeting neuroinflammation seems to be crucial in terms of yielding successful individual therapeutic strategies.

Screening the Coulomb interaction leads to a prethermal regime in two-dimensional bad conductors.

The absence of thermalization in certain isolated many-body systems is of great fundamental interest. Many-body localization (MBL) is a widely studied mechanism for thermalization to fail in strongly disordered quantum systems, but it is still not understood precisely how the range of interactions affects the dynamical behavior and the existence of MBL, especially in dimensions D > 1. By investigating nonequilibrium dynamics in strongly disordered D = 2 electron systems with power-law interactions ∝ 1/r and poor coupling to a thermal bath, here we observe MBL-like, prethermal dynamics for α = 3.

Reimbursement decision-making system in Poland systematically compared to other countries.

Our objective was to analyze and compare systematically and structurally reimbursement systems in Poland and other countries. The systems were selected based on recommendations issued by the Polish Agency for Health Technology Assessment and Tariffication (AHTAPol), which explicitly referred to other countries and agencies). Consequently, apart from Poland, the countries included in the analysis were England, Scotland, Wales, Ireland, France, Netherlands, Germany, Norway, Sweden, Canada, Australia and New Zealand.

Anomalous Landau quantization in intrinsic magnetic topological insulators.

The intrinsic magnetic topological insulator, Mn(BiSb)Te, has been identified as a Weyl semimetal with a single pair of Weyl nodes in its spin-aligned strong-field configuration. A direct consequence of the Weyl state is the layer dependent Chern number, [Formula: see text]. Previous reports in MnBiTe thin films have shown higher [Formula: see text] states either by increasing the film thickness or controlling the chemical potential.

The impact of changing the funding model for genetic diagnostics and improved access to personalized medicine in oncology.

Aim: In January 2017, a new funding model for diagnostic genetic testing in cancer was introduced in Poland.

Objectives: The aim of this study was to assess the impact of changing the funding model for genetic diagnosis in oncology on improving access to personalized medicine in Poland between 2017 and 2019.

Methods: The analysis included data on settlements with the National Health Fund for genetic tests in cancer under a contract of the hospital treatment type and under the contract in the type of separately contracted services between 2017 and 2019.

Economic Costs of Cardiovascular Diseases in Poland Estimates for 2015-2017 Years.

Background: Cardiovascular diseases are associated with growing public and private expenditure on healthcare regardless geographic region. Therefore, it is necessary to accurately estimate the overall societal costs-both direct and indirect expenses from the perspective of patients, caregivers and employers.

Research Design: The aim of this paper is to determine the direct and indirect costs related to cardiovascular diseases in Poland from 2015 to 2017.

Overview and Analysis of the Cost of Drug Programs in Poland: Public Payer Expenditures and Coverage of Cancer and Non-Neoplastic Diseases Related Drug Therapies from 2015-2018 Years.

Background: In Poland drug programmes developed by the Minister of Health and financed by the National Health Fund are special reimbursement frameworks of innovative, expensive, and mostly hospital based medical products used for a small number of patients.

Research Design: The research presented in this paper is based on data analysis published by the National Health Fund in Poland. The analysis focused on estimating public payer expenditure on drugs available within drug programmes from 2015 to 2018.

45.5-tesla direct-current magnetic field generated with a high-temperature superconducting magnet.

Strong magnetic fields are required in many fields, such as medicine (magnetic resonance imaging), pharmacy (nuclear magnetic resonance), particle accelerators (such as the Large Hadron Collider) and fusion devices (for example, the International Thermonuclear Experimental Reactor, ITER), as well as for other diverse scientific and industrial uses. For almost two decades, 45 tesla has been the highest achievable direct-current (d.c.

[Cytostatic and cytotoxic waste - rules of conduct in Poland].

Poland is one of the European countries with the highest level of production of dangerous medical waste. Although in Europe the volume of produced cytotoxic and cytostatic waste (used in chemotherapy by oncological patients) has been declining for several years, in Poland a reverse trend has been observed. As this waste puts the safety of medical workers and patients at risk, special handling procedures are required to limit the harmful effect of these drugs on human health.

Brain Functional Reserve in the Context of Neuroplasticity after Stroke.

Stroke is the second cause of death and more importantly first cause of disability in people over 40 years of age. Current therapeutic management of ischemic stroke does not provide fully satisfactory outcomes. Stroke management has significantly changed since the time when there were opened modern stroke units with early motor and speech rehabilitation in hospitals.

Hole pocket-driven superconductivity and its universal features in the electron-doped cuprates.

After three decades of intensive research attention, the emergence of superconductivity in cuprates remains an unsolved puzzle. One major challenge has been to arrive at a satisfactory understanding of the unusual metallic "normal state" from which the superconducting state emerges upon cooling. A second challenge has been to achieve a unified understanding of hole- and electron-doped compounds.

The direct and indirect costs of epilepsy in Poland estimates for 2014-2016 years.

Background: According to the current data, around 1% of the Poland population have epilepsy, which comprises about 400,000 people. This group of patients requires life-long therapy including both drug therapy and hospitalization. The character of the epilepsy has a significant impact on the expenses borne by individual patients, and the prevalence of the disease has a significant impact on the health care system.

J (4.2 K, 31.2 T) beyond 1 kA/mm of a ~3.2 μm thick, 20 mol% Zr-added MOCVD REBCO coated conductor.

A main challenge that significantly impedes REBaCuO (RE = rare earth) coated conductor applications is the low engineering critical current density J because of the low superconductor fill factor in a complicated layered structure that is crucial for REBaCuO to carry supercurrent. Recently, we have successfully achieved engineering critical current density beyond 2.0 kA/mm at 4.

Selective mass enhancement close to the quantum critical point in BaFe(As P ).

A quantum critical point (QCP) is currently being conjectured for the BaFe(As P ) system at the critical value x  ≈ 0.3. In the proximity of a QCP, all thermodynamic and transport properties are expected to scale with a single characteristic energy, given by the quantum fluctuations.

A Feasibility Study of High-Strength Bi-2223 Conductor for High-Field Solenoids.

We performed a feasibility study on a high-strength Bi Pb SrCaCuO (Bi-2223) tape conductor for high-field solenoid applications. The investigated conductor, DI-BSCCO Type HT-XX, is a pre-production version of Type HT-NX, which has recently become available from Sumitomo Electric Industries (SEI). It is based on their DI-BSCCO Type H tape, but laminated with a high-strength Ni-alloy.

High-field transport properties of a P-doped BaFeAs film on technical substrate.

High temperature (high-T) superconductors like cuprates have superior critical current properties in magnetic fields over other superconductors. However, superconducting wires for high-field-magnet applications are still dominated by low-T NbSn due probably to cost and processing issues. The recent discovery of a second class of high-T materials, Fe-based superconductors, may provide another option for high-field-magnet wires.

Intrinsic and extrinsic pinning in NdFeAs(O,F): vortex trapping and lock-in by the layered structure.

Fe-based superconductors (FBS) present a large variety of compounds whose properties are affected to different extents by their crystal structures. Amongst them, the REFeAs(O,F) (RE1111, RE being a rare-earth element) is the family with the highest critical temperature T but also with a large anisotropy and Josephson vortices as demonstrated in the flux-flow regime in Sm1111 (T ∼ 55 K). Here we focus on the pinning properties of the lower-T Nd1111 in the flux-creep regime.

A route for a strong increase of critical current in nanostrained iron-based superconductors.

The critical temperature T and the critical current density J determine the limits to large-scale superconductor applications. Superconductivity emerges at T. The practical current-carrying capability, measured by J, is the ability of defects in superconductors to pin the magnetic vortices, and that may reduce T.