Publications by authors named "Jaroslaw Wawryn"
Yeast (Saccharomyces cerevisiae) mutants lacking CuZn-superoxide dismutase (CuZnSOD) are hypersensitive to oxygen and have significantly decreased replicative life span. Both these defects can be ameliorated by exogenous ascorbate. The effect of ascorbate on life span is complicated by auto-oxidation of its compound in the medium.
View Article and Find Full Text PDFMitochondrial dysfunction induces a signaling pathway, which culminates in changes in the expression of many nuclear genes. This retrograde response, as it is called, extends yeast replicative life span. It also results in a marked increase in the cellular content of extrachromosomal ribosomal DNA circles (ERCs), which can cause the demise of the cell.
View Article and Find Full Text PDFArticle Synopsis
- The study examined how the lack of Cu,Zn-superoxide dismutase (CuZnSOD) affects the lifespan and division rates of the yeast Saccharomyces cerevisiae under various oxygen levels.
- Results showed that both strains of yeast had similar replicative lifespans and division rates in air, low oxygen (hypoxic), and no oxygen (anoxic) conditions.
- This suggests that the negative impacts of missing CuZnSOD go beyond just increased superoxide levels and involve other cellular functions.