Publications by authors named "Jaroslava Sebestova"
Mechanistic basis of infertility of mouse intersubspecific hybrids.
Proc Natl Acad Sci U S A
February 2013
According to the Dobzhansky-Muller model, hybrid sterility is a consequence of the independent evolution of related taxa resulting in incompatible genomic interactions of their hybrids. The model implies that the incompatibilities evolve randomly, unless a particular gene or nongenic sequence diverges much faster than the rest of the genome. Here we propose that asynapsis of heterospecific chromosomes in meiotic prophase provides a recurrently evolving trigger for the meiotic arrest of interspecific F1 hybrids.
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- Chromosome segregation errors occur frequently during female meiosis in mammals, especially as maternal age increases, leading to potential issues in embryo development.
- The spindle assembly checkpoint (SAC) in oocytes is crucial for preventing errors by slowing down the cell cycle when kinetochores are unaligned, but its effectiveness differs from that in somatic cells.
- Research using live cell imaging indicates that while oocytes can tolerate multiple unaligned kinetochores during the transition from metaphase to anaphase, the mechanisms for detecting and correcting these errors are inadequate, contributing to the risk of aneuploidy in embryos.