Publications by authors named "Jaroslav Pazout"
Article Synopsis
- Acute supraventricular arrhythmias can worsen hemodynamic stability in patients with septic shock, and a study compared the effects of intravenous propafenone and amiodarone on arrhythmias in this population.
- In a trial with 209 patients, those receiving propafenone had a quicker return to sinus rhythm (3.7 hours) compared to those on amiodarone (7.3 hours), although the overall 24-hour sinus rhythm rates were similar.
- Propafenone led to fewer cases of arrhythmia recurrence than amiodarone, especially in patients without a dilated left atrium, indicating it may be a more effective option for short-term management.
Article Synopsis
- Supraventricular arrhythmias can worsen blood flow issues in patients with septic shock, leading researchers to hypothesize that propafenone might be more effective than amiodarone for restoring normal heart rhythm.
- The study will involve septic shock patients experiencing new arrhythmias but with stable left ventricular function, randomly assigning them to receive either drug and measuring their rhythm control after 24 hours.
- Results will also analyze the need for rescue treatments, mortality rates, and factors predicting successful rhythm control and recurrent arrhythmias, with a target enrollment of 200 patients to validate the findings.
Background: The implementation of standardized protocols for management of polytrauma, multiple injuries and complicated monotrauma has led to improvement in trauma care with decrease in posttraumatic morbidity and mortality. The introduction of algorithm "Definitive Surgical Trauma Care" (DSTC) with concept of "damage control" surgery assumed the principal role in care of polytrauma patients. It can be accomplished only in the trauma- centre with implementation of care system for severely injured patients.
View Article and Find Full Text PDFObjectives: To estimate the efficacy and metabolic effects of growth hormone substitution as intravenous pulses together with alanyl-glutamine supplementation and tight blood glucose control in prolonged critical illness.
Design: Prospective double-blind, randomized trial with open-label control arm.
Setting: Intensive care unit of tertiary level hospital.
Objective: We aim to demonstrate that low dose growth hormone (GH) administered in i.v. pulses every 3h is able to normalize IGF-I levels in subjects with prolonged critical illness, after multiple trauma.
View Article and Find Full Text PDFBackground: Dipeptide alanyl-glutamine is a commonly used substrate in major trauma patients. Its importance and effects are widely discussed; as yet, it has not been elucidated whether its administration influences glucose homeostasis.
Objective: We studied the effect of alanyl-glutamine administration on insulin resistance.