Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson's disease.

Objective: Mutations in the α-synuclein-encoding gene SNCA are considered as a rare cause of Parkinson's disease (PD). Our objective was to examine the frequency of the SNCA point mutations among PD patients of Polish origin.

Methods: Detection of the known SNCA point mutations A30P (c.