Publications by authors named "Jarmo-Charles J Kalinski"
Bacterial symbionts are critical members of many marine sponge holobionts. Some sponge-associated bacterial lineages, such as Poribacteria, sponge-associated unclassified lineage (SAUL), and Tethybacterales, appear to have broad-host ranges and associate with a diversity of sponge species, while others are more species-specific, having adapted to the niche environment of their host. Host-associated spirochete symbionts that are numerically dominant have been documented in several invertebrates including termites, starfish, and corals.
View Article and Find Full Text PDFFeature-based molecular networking (FBMN) is a popular analysis approach for liquid chromatography-tandem mass spectrometry-based non-targeted metabolomics data. While processing liquid chromatography-tandem mass spectrometry data through FBMN is fairly streamlined, downstream data handling and statistical interrogation are often a key bottleneck. Especially users new to statistical analysis struggle to effectively handle and analyze complex data matrices.
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- Microbialites, which are layered structures formed by microbial mats, are abundant in the fossil record and are currently being identified worldwide, presenting a challenge for understanding their formation and environmental functions.
- Researchers conducted a study on living stromatolites in South Africa, collecting samples from various locations to analyze the composition and small molecule production of microbial communities using advanced techniques like gene sequencing and metabolomics.
- The study identified a new group of metabolites called ibhayipeptolides, highlighting the diverse chemistry present in these microbialites and paving the way for future research on their roles and functions in the environment.
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- Anthropogenic pollution poses a significant threat to aquatic ecosystems, particularly in coastal areas of the Global South, where knowledge of harmful compounds in Dissolved Organic Matter (DOM) is lacking.
- This study utilized non-targeted tandem mass spectrometry to analyze the DOM composition in Algoa Bay and its two estuaries, revealing a wide range of pollutants including pharmaceuticals and pesticides.
- Results showed that the urbanized Swartkops Estuary was dominated by urban pollutants, while the Sundays Estuary was mainly affected by agrochemicals from agriculture, highlighting the diverse sources of pollution in the region.
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- Pyrroloiminoquinones are cytotoxic alkaloids found mainly in marine sponges, characterized by a unique tricyclic structure and include compounds like makaluvamines and tsitsikammamines.
- These compounds demonstrate a wide range of biological activities, such as anticancer, antimicrobial, and antiviral effects, along with the ability to inhibit important cellular enzymes.
- The review highlights recent research on the structural diversity, distribution, and synthesis of pyrroloiminoquinones, emphasizing their potential for drug development and the exploration of new synthetic analogs.
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- Sponges from the Latrunculiidae family are known to produce unique bioactive compounds called pyrroloiminoquinone alkaloids, including several types like makaluvamines and discorhabdins.
- This study utilized advanced methods to analyze chemical extracts from various species of these sponges, identifying over 200 different pyrroloiminoquinones and related compounds with distinct profiles for each species.
- Key findings include that new species have similar but unique chemical traits compared to known ones, highlighting the diversity and potential of these compounds for further research and development.
The temperate marine sponge, , produces pyrroloiminoquinone alkaloids with potential as anticancer drug leads. We profiled the secondary metabolite reservoir of sponges using HR-ESI-LC-MS/MS-based molecular networking analysis followed by preparative purification efforts to map the diversity of new and known pyrroloiminoquinones and related compounds in extracts of seven specimens. Molecular taxonomic identification confirmed all sponges as and five specimens (chemotype I) were found to produce mainly discorhabdins and tsitsikammamines.
View Article and Find Full Text PDFSponges are important sources of bioactive secondary metabolites. These compounds are frequently synthesized by bacterial symbionts, which may be recruited from the surrounding seawater or transferred to the sponge progeny by the parent. In this study, we investigated the bacterial communities associated with the sponge Samaai and Gibbons 2005.
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