Publications by authors named "Jarka Naser"
Nano-indentation techniques might be better equipped to assess the heterogeneous material properties of plaques than macroscopic methods but there are no bespoke protocols for this kind of material testing for coronary arteries. Therefore, we developed a measurement protocol to extract mechanical properties from healthy and atherosclerotic coronary artery tissue sections. Young's modulus was derived from force-indentation data.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on how the endothelium of coronary arteries is affected by wall shear stress and vessel wall strain, which are important for understanding artery health.
- Researchers developed fluid-structure interaction (FSI) models for three specific coronary arteries, incorporating real experimental geometries and conditions to analyze the biomechanics more accurately.
- Findings showed that incorporating bending in the models significantly altered shear stress metrics and wall strain, indicating that analyses should consider the unique bending characteristics of each vessel to better understand coronary artery behavior.
Shear stress is known to affect many processes in (patho-) physiology through a complex, multi-molecular mechanism, termed mechanotransduction. The sheer complexity of the process has raised questions how mechanotransduction is regulated. Here, we comprehensively evaluate the literature about the role of small non-coding miRNA in the regulation of mechanotransduction.
View Article and Find Full Text PDF