Benzaldehyde and azaphilone derivatives from the marine-derived fungus PSU-AMF89.

Two new compounds including one benzaldehyde () and one azaphilone () were isolated from the marine-derived fungus PSU-AMF89 together with nine known compounds (-). Their structures were determined by spectroscopic evidences. The absolute configuration of was established by comparison of the ECD data with those of the previously reported data of compound as well as the biosynthetic consideration.

Penicitrisochromans A-C, new isochromans from the marine-derived fungus PSU-MF100.

Three new isochroman derivatives, penicitrisochromans A-C (-), together with 25 known polyketides were isolated from the marine-derived fungus PSU-MF100. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of and were established by comparison of specific rotations and electronic circular dichroism (ECD) data with those of the known co-metabolite whereas those of were assigned based on the ECD calculation and biosynthetic consideration.

Talarostatin, a vermistatin derivative from the soil-derived fungus PSU-SPSF059.

The soil-derived fungus PSU-SPSF059 produced one new vermistatin derivative, talarostatin, and seven known compounds including two vermistatins, two chrodrimanins, two diphenyl ethers and one penicillide derivative. Extensive spectroscopic analysis was performed to identify their structures. The absolute configuration of talarostatin was determined by comparing the experimental and calculated electronic circular dichroism data.

Morphology, Phenotype, and Molecular Identification of Clinical and Environmental Species Complex Isolates from Malaysia.

infections in humans (fusariosis) and in economically important plants involve species of several species complexes. Species of the species complex (FSSC) are the most frequent cause of human fusariosis. The FSSC comprises more than 60 closely related species that can be separated into three major clades by multi-locus sequence typing (MLST) using translation elongation factor 1-alpha () and RNA polymerase II () DNA sequences.

Furanone, morpholinone and tetrahydrofuran derivatives from the marine-derived fungus sp. PSU-MF07.

Three new compounds including one furanone, one morpholinone and one tetrahydrofuran together with three known compounds were isolated from the broth extract of the marine-derived fungus sp. PSU-MF07. The structures of the isolated compounds were determined on the basis of spectroscopic methods.

Sesquiterpenes from the soil-derived fungus PSU-SPSF346.

Two new sesquiterpenes, trichocitrinovirenes A () and B (), and five known compounds including four structurally related sesquiterpenes and one γ-lactone were isolated from the soil-derived fungus PSU-SPSF346. The structures were identified by analysis of their spectroscopic data. The relative configuration was assigned based on NOEDIFF data.

A nonadride derivative from the marine-derived fungus PSU-AMF79.

One new nonadride enantiomer, -epiheveadride, along with five known dioxopiperazine derivatives were isolated from the marine-derived fungus PSU-AMF79. Their structures were identified by extensive spectroscopic analysis. The absolute configuration of -epiheveadride was determined by comparison of the specific rotation and electronic circular dichroism data with those of related known compounds.

-Pyrone and decalin derivatives from the marine-derived fungus PSU-MF79.

Two new compounds, one -pyrone (trichoharzianone) and one decalin (trichoharzianin), along with eight known compounds including three decalins, two -lactones, two carboxylic acids and one isochroman were isolated from the marine-derived fungus PSU-MF79. The structures were determined by spectroscopic methods. The relative configuration of trichoharzianin was assigned based on NOEDIFF data and coupling constants whereas the absolute configurations were established by comparison of electronic circular dichroism data with those of the co-metabolites.

2-Oxaspiro[4.5]decane and -pyrenocine derivatives from the endophytic fungus sp. PSU-H51.

One new 2-oxaspiro[4.5]decane, roussoellide, and one new pyrenocine, 2,3-dihydropyrenocine A, together with nine known compounds including known arthropsolide A, and pyrenocines A and E, were obtained from the culture broth of the endophytic fungus sp. Their structures were determined using spectroscopic data.

Dimeric γ-lactone derivatives from the soil-derived fungus NSTRU-PN1.4.

Investigation of the soil-derived fungus NSTRU-PN1.4 resulted in the isolation of five dimeric γ-lactones including two new botryosphaerilactones D and E ( and ) and three known structurally related analogoues () along with seven known compounds. Their structures were elucidated by extensive spectroscopic analysis.

Limonoids from fruiting bodies of the wood-rot basidiomycete Fulvifomes xylocarpicola associated with the mangrove tree Xylocarpus granatum.

Three previously undescribed limonoids, fulvifomins A-C, together with two known compounds, 6-deoxydetigloyl-swietenine acetate and methyl angolensate, were isolated from fruiting bodies of the wood-rot fungus Fulvifomes xylocarpicola (Hymenochaetaceae), growing on the mangrove tree Xylocarpus granatum (Meliaceae). The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data, and X-ray crystallographic analysis (for fulvifomin A). A number of similar limonoids have been isolated from higher plants of the family Meliaceae, including X.

Depsidones and a dihydroxanthenone from the endophytic fungi Simplicillium lanosoniveum (J.F.H. Beyma) Zare & W. Gams PSU-H168 and PSU-H261.

Three new compounds including two depsidones (simplicildones J and K) and one dihydroxanthenone (globosuxanthone E) together with nine known compounds were obtained from the crude extracts of two endophytic fungi Simplicillium lanosoniveum (J.F.H.

Trichothecenes from a Soil-Derived Trichoderma brevicompactum.

Six new (1-6), together with seven known (7-13), trichothecenes were isolated from the soil-derived Trichoderma brevicompactum PSU-RSPG27. Their structures were established using spectroscopic data. The structure of 1 was confirmed by X-ray data.

Asperidines A-C, pyrrolidine and piperidine derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178.

One new pyrrolidine derivative, asperidine A (1), and two new piperidine derivatives, asperidines B (2) and C (3), were isolated from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178 together with two known alkaloids. Compound 3 possessed an unprecedented 7-oxa-1-azabicyclo[3.2.

Depsidones and an α-pyrone derivative from Simplicillium sp. PSU-H41, an endophytic fungus from Hevea brasiliensis leaf [corrected].

Nine previously undescribed depsidones (simplicildones A-I) and one previously undescribed α-pyrone (simplicilopyrone) were isolated from the endophytic fungus Simplicillium sp. PSU-H41 along with 11 known compounds. Their structures were established by extensive spectroscopic analysis.

γ-Butenolide and furanone derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178.

Chromatographic separation of the broth extract of the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178 resulted in isolation of four γ-butenolide-furanone dimers, aspersclerotiorones A-D, a furanone derivative, aspersclerotiorone E, and two γ-butenolide derivatives, aspersclerotiorones F and G, together with six known compounds, penicillic acid, dihydropenicillic acid, 5,6-dihydro-6-hydroxypenicillic acid, 6-methoxy-5,6-dihydropenicillic acid, coculnol and (4R,5R)-4,5-dihydroxy-3-methoxy-5-methylcyclohex-2-en-1-one. Their structures were determined by spectroscopic evidence. For aspersclerotiorones A and B, the structures were confirmed by single-crystal X-ray diffraction crystallography.

Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178.

Three new lovastatin analogues (1, 4, and 5) together with four known lovastatin derivatives, namely, lovastatin (2), α,β-dehydrolovastatin (3), α,β-dehydrodihydromonacolin K (6), and α,β-dehydro-4a,5-dihydromonacolin L (7), were isolated from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178. Their structures were established using spectroscopic evidence. Compound 5 exhibited the most potent activity against HMG-CoA reductase, with an IC50 value of 387 μM.

Terezine derivatives from the fungus Phoma herbarum PSU-H256.

Investigation of the fungus Phoma herbarum PSU-H256 isolated from a leaf of Hevea brasiliensis resulted in the isolation of eight terezine derivatives (E-L) together with four known compounds. Their structures were established by analysis of spectroscopic evidence. For terezines E and H, their structures were confirmed by single-crystal X-ray diffraction crystallography.

Xylariphilone: a new azaphilone derivative from the seagrass-derived fungus Xylariales sp. PSU-ES163.

One new azaphilone derivative, named xylariphilone (1), along with 10 known compounds was isolated from the seagrass-derived fungus Xylariales sp. PSU-ES163. Their structures were elucidated on the basis of extensive spectroscopic analysis.

A new hydronaphthalenone from the mangrove-derived Daldinia eschscholtzii PSU-STD57.

One new hydronaphthalenone derivative (1) was isolated from the broth extract of the endophytic fungus Daldinia eschscholtzii PSU-STD57 together with five known compounds, isosclerone (2), 8-methoxy-1-naphthol, 1,8-dimethoxynaphthalene, 2,6-dihydroxyphenyl-1-butan-1-one and tyrosol. The structures were assigned by spectroscopic methods. All the compounds were tested for antimicrobial activity against Staphylococcus aureus, methicillin-resistant S.

Eremophilane Sesquiterpenes and Diphenyl Thioethers from the Soil Fungus Penicillium copticola PSU-RSPG138.

Four new compounds including two eremophilane sesquiterpenes, penicilleremophilanes A (1) and B (2), as well as two sulfur-containing biphenols, penicillithiophenols A (3) and B (4), were isolated from the soil fungus Penicillium copticola PSU-RSPG138 together with 16 known compounds. Their structures were elucidated by spectroscopic methods. Known sporogen AO-1 exhibited significant antimalarial activity against Plasmodium falciparum with an IC50 value of 1.