Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation.

Diabetes is associated with increased cardiac injury and sudden death. Nicotinamide phosphoribosyltransferase (Nampt) is an essential enzyme for the NAD salvage pathway and is dysregulated in diabetes. Nampt activation results in rescued NADH/NAD ratios and provides pharmacological changes necessary for diabetic cardioprotection.