Publications by authors named "Jared W Taylor"
Background: Predicting Alzheimer's disease (AD) and frontotemporal dementia (FTD) using polygenic risk scores (PRS) for late‐onset forms holds promise, but its accuracy might be influenced by social determinants of health (SDOH). This study explores how considering SDOH alongside genes can improve prediction, focusing on potential differences for each disease.
Methods: Employing logistic regression in 677 individuals (287 AD, 102 FTD, and 288 controls) aged 40‐80 from the ReDLat study across six Latin American countries, we investigated the potential for SDOH to modify the association between PRS and susceptibility to AD and FTD.
Article Synopsis
- Latin America's genetic diversity offers a unique opportunity to study Alzheimer's disease (AD) and frontotemporal dementia (FTD), with a focus on identifying related genetic variations.
- The study involved 2,162 participants from six countries who underwent extensive genomic sequencing and analysis to detect genetic factors linked to these dementias.
- Results highlighted a mix of American, African, and European ancestries, discovered 17 pathogenic variants, and revealed specific genetic variations tied to AD and FTD inheritance patterns in affected families.
Tauopathies are a group of neurodegenerative diseases defined by abnormal aggregates of tau, a microtubule-associated protein encoded by MAPT. MAPT expression is near absent in neural progenitor cells (NPCs) and increases during differentiation. This temporally dynamic expression pattern suggests that MAPT expression could be controlled by transcription factors and cis-regulatory elements specific to differentiated cell types.
View Article and Find Full Text PDFEarly-onset Alzheimer's disease explained by polygenic risk of late-onset disease?
Alzheimers Dement (Amst)
September 2023
Article Synopsis
- * A study applied a polygenic hazard score to early-onset AD patients and found that their scores were similar to those of late-onset patients, suggesting that genetic factors associated with late-onset AD do not explain early-onset cases.
- * The research indicates that early-onset AD has a distinct genetic makeup compared to late-onset AD, highlighting the need for further investigation into unique genetic factors related to early-onset AD.
Contributions of rare and common variation to early-onset and atypical dementia risk.
Cold Spring Harb Mol Case Stud
June 2023
Article Synopsis
- - The study analyzed genomic data from 100 patients with early-onset or atypical dementia, including 68 newly described cases, predominantly composed of white, non-Hispanic individuals.
- - Among the cohort, 53% had a returnable genetic variant, with 5 patients identified as having pathogenic variants according to established medical criteria.
- - A comparison of polygenic risk scores revealed that early-onset Alzheimer's patients had higher scores than those with late-onset Alzheimer's, indicating both rare and common genetic factors contribute to the risk of early-onset neurodegenerative diseases.
Background: Tauopathies are a group of neurodegenerative diseases driven by abnormal aggregates of tau, a microtubule associated protein encoded by the gene. expression is absent in neural progenitor cells (NPCs) and increases during differentiation. This temporally dynamic expression pattern suggests that expression is controlled by transcription factors and cis-regulatory elements specific to differentiated cell types.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on a Colombian family with a specific genetic mutation related to early-onset Alzheimer's disease, aiming to find genetic factors that affect the age at which the disease manifests.
- - Researchers analyzed genetic data from 340 individuals carrying the PSEN1 E280A mutation and found 13 genetic variants linked to Alzheimer's onset, with three significant variants associated with the gene clusterin.
- - The identified genetic variants are suggested to influence biological processes related to Alzheimer’s, highlighting their possible importance in developing future therapies, especially given the strong existing mutation linked to the disease.
We collected and analyzed genomic sequencing data from individuals with clinician- diagnosed early-onset or atypical dementia. Thirty-two patients were previously described, with sixty-eight newly described in this report. Of those sixty-eight, sixty-two patients reported Caucasian, non-Hispanic ethnicity and six reported as African American, non-Hispanic.
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