Surface Modification Using Ultraviolet-Ozone Treatment Enhances Acute Drug Transfer in Drug-Coated Balloon Therapy.

Endovascular deployment of drug-coated balloons (DCB) is an emerging strategy for the revascularization of arterial disease. Randomized clinical trials have demonstrated DCB effectiveness, but a recent meta-analysis reported increased mortality risk in humans with use of DCBs containing the common antiproliferative drug paclitaxel. While many factors could have contributed to adverse outcomes, current DCB designs have poor drug delivery efficiency, risk of systemic toxicity, and limited potential to retain therapeutic drug concentrations within the arterial wall following the procedure.

Estimation of Size and Contact Angle of Evaporating Sessile Liquid Drops Using Texture Analysis.

Size and contact angle of liquid drops are fundamental parameters in interfacial science. Accurate estimation of these parameters can provide objective information regarding several properties of the contacting surface. We leveraged principles of texture analysis to estimate the contact angle and the drop diameter from videos of evaporating sessile liquid drops deposited on solid surfaces.