Publications by authors named "Jared S Shless"
Objective: Epilepsy is a common neurological disorder affecting 1% of the global population. Loss of consciousness in focal impaired awareness seizures (FIASs) and focal-to-bilateral tonic-clonic seizures (FBTCSs) can be devastating, but the mechanisms are not well understood. Although ictal activity and interictal connectivity changes have been noted, the network states of focal aware seizures (FASs), FIASs, and FBTCSs have not been thoroughly evaluated with network measures ictally.
View Article and Find Full Text PDFArticle Synopsis
- Connectome-based analyses may enhance the detection of seizure onset zones (SOZs) in drug-resistant epilepsy, focusing on interictal suppression hypothesis (ISH) patterns.
- Unsupervised machine learning techniques were applied to resting-state SEEG data from 81 patients to identify specific network motifs that indicate SOZs.
- While the ISH motif (high inward and low outward connectivity) was common and effective in identifying SOZs in 79% of patients, additional unique motifs were observed, highlighting the patient-specific nature of seizure networks.
Objective: This study sought to characterize resting-state functional MRI (fMRI) connectivity patterns of the posterior hypothalamus (pHTH) and the nucleus basalis of Meynert (NBM) in surgical patients with mesial temporal lobe epilepsy (mTLE), and to investigate potential correlations between functional connectivity of these arousal regions and neurocognitive performance.
Methods: The study evaluated resting-state fMRI in 60 patients with preoperative mTLE and in 95 healthy controls. The authors first conducted voxel-wise connectivity analyses seeded from the pHTH, combined anterior and tuberal hypothalamus (atHTH; i.
Article Synopsis
- Scientists are investigating why people with focal epilepsy don't experience constant seizures, suggesting that the brain's network may actively suppress them during non-seizure states.
- Recent studies show seizure-onset areas have increased inward connectivity, indicating they may work with the rest of the brain to prevent seizures from occurring.
- Researchers tested this hypothesis in 81 individuals with drug-resistant focal epilepsy, finding significant differences in brain connectivity patterns that could help identify areas involved in seizure generation without needing extensive recordings.
Many healthcare professionals have been forced, under acute shortages, to extend medical exam gloves beyond their intended single use. Despite limited available literature, the CDC proposed a set of guidelines for repeated exam gloves use, indicating a maximum number of treatments for three widely available disinfectants. This study examines how these treatments affect the mechanical properties of latex and nitrile gloves.
View Article and Find Full Text PDFCOVID-19 has created shortages of personal protective equipment. In resource-constrained situations, limited cycles of disinfection and extended use of gloves is recommended by the U.S.
View Article and Find Full Text PDF