Publications by authors named "Jared M CroweTipton"
J Am Chem Soc
February 2019
Article Synopsis
- There is growing interest in diversifying polyketides, which are bioactive molecules, by engineering the acyltransferase (AT) domains in polyketide synthases (PKSs) to incorporate non-natural extender units.
- Past attempts have mostly relied on naturally promiscuous ATs or those in terminal modules, which limits the study of ATs with lower promiscuity and their interactions with downstream domains.
- Recent research on the pikromycin PKS explored the substrate preferences of its last two modules, leading to successful engineering of specificity for non-natural derivatives and revealing new metabolites influenced by downstream processing, paving the way for future polyketide advancements.
