Publications by authors named "Jared Khan"
Unlabelled: The THEORY study evaluated the effects of single and multiple doses of obinutuzumab, a type 2 anti-CD20 antibody that induces antibody-dependent cell-mediated cytotoxicity and direct cell death, in combination with standard of care in patients with end-stage renal disease.
Methods: We measured B-cell subsets and protein biomarkers of B-cell activity in peripheral blood before and after obinutuzumab administration in THEORY patients, and B-cell subsets in lymph nodes in THEORY patients and an untreated comparator cohort.
Results: Obinutuzumab treatment resulted in a rapid loss of B-cell subsets (including naive B, memory B, double-negative, immunoglobulin D transitional cells, and plasmablasts/plasma cells) in peripheral blood and tissue.
Obesity confers an independent risk for carcinogenesis. Classically viewed as a genetic disease, owing to the discovery of tumor suppressors and oncogenes, genetic events alone are not sufficient to explain the progression and development of cancers. Tumor development is often associated with metabolic and immunological changes.
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- Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a serious, life-threatening condition with no current treatments that change the disease course.
- Researchers discovered that certain mutations in TTR destabilize its normal form, while the T119M variant helps stabilize it, preventing disease.
- The study highlights the importance of molecular interactions and binding enthalpy for creating effective TTR stabilizers, specifically focusing on the stabilizer AG10, and introduces a new dog model for studying the effects of these stabilizers on ATTR-CM.