Publications by authors named "Jared J Bearss"
Patterns and Significance of PIM Kinases in Urothelial Carcinoma.
Appl Immunohistochem Mol Morphol
August 2016
Background: The Provirus integrating site Moloney murine leukemia virus (Pim) family are proteins with serine/threonine kinase activity. Studies have demonstrated overexpression of Pims in cancer. To our knowledge, only a single study has examined Pim-1 in urothelial carcinoma.
View Article and Find Full Text PDFThe proto-oncogene proviral integration site for moloney murine leukemia virus (PIM) kinases (PIM-1, PIM-2, and PIM-3) are serine/threonine kinases that are involved in a number of signaling pathways important to cancer cells. PIM kinases act in downstream effector functions as inhibitors of apoptosis and as positive regulators of G1-S phase progression through the cell cycle. PIM kinases are upregulated in multiple cancer indications, including lymphoma, leukemia, multiple myeloma, and prostate, gastric, and head and neck cancers.
View Article and Find Full Text PDFArticle Synopsis
- The receptor tyrosine kinase AXL is a promising target for cancer treatment due to its overexpression and role in tumor growth and metastasis.
- Researchers developed a homology model of AXL's catalytic domain to screen for small molecule inhibitors.
- They created a series of 2,4,5-trisubstituted pyrimidines that effectively inhibited AXL and reduced growth in pancreatic cancer cell lines, with an impressive IC(50) of 19 nM.