Association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case-control study.

Background: Both vaccination and physical activity have been shown to independently decrease the likelihood of severe COVID-19 infection.

Objective: To assess the association between regular physical activity and vaccination against COVID-19 among healthcare workers.

Methods: A test negative case-control study design was used to estimate the risk of having an associated COVID-19-related hospital admission, among individuals who were unvaccinated compared with those who were fully vaccinated with Ad26.

Effectiveness of the Ad26.COV2.S vaccine in health-care workers in South Africa (the Sisonke study): results from a single-arm, open-label, phase 3B, implementation study.

Background: We aimed to assess the effectiveness of a single dose of the Ad26.COV2.S vaccine (Johnson & Johnson) in health-care workers in South Africa during two waves of the South African COVID-19 epidemic.