Publications by authors named "Jared Cayton"
Article Synopsis
- - The study addresses the challenges of controlling schistosomiasis, particularly focusing on genetic methods to disrupt the transmission of the parasite Schistosoma mansoni, mainly through research on its snail vector, Biomphalaria, with an emphasis on the underrepresented African species.
- - Researchers generated the first genome assembly of Biomphalaria sudanica from Lake Victoria, revealing a haploid genome size of ~944.2 Mb with 23,598 genes, and demonstrating the presence of immune-related genes similar to those in the South American snail, B. glabrata.
- - The findings highlight significant genetic diversity in immune-related genomic regions, particularly in the PTC2 region, suggesting a potentially enhanced immune response against S. mans
Background: Control and elimination of schistosomiasis is an arduous task, with current strategies proving inadequate to break transmission. Exploration of genetic approaches to interrupt transmission, the causative agent for human intestinal schistosomiasis in sub-Saharan Africa and South America, has led to genomic research of the snail vector hosts of the genus Few complete genomic resources exist, with African species being particularly underrepresented despite this being where the majority of infections occur. Here we generate and annotate the first genome assembly of sensu lato, a species responsible for transmission in lake and marsh habitats of the African Rift Valley.
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