Publications by authors named "Jared Atlas"
New genes (or young genes) are genetic novelties pivotal in mammalian evolution. However, their phenotypic impacts and evolutionary patterns over time remain elusive in humans owing to the technical and ethical complexities of functional studies. Integrating gene age dating with Mendelian disease phenotyping, we reveal a gradual rise in disease gene proportion as gene age increases.
View Article and Find Full Text PDFNew genes (or young genes) are genetic novelties pivotal in mammalian evolution. However, their phenotypic impacts and evolutionary patterns over time remain elusive in humans due to the technical and ethical complexities of functional studies. Integrating gene age dating with Mendelian disease phenotyping, our research shows a gradual rise in disease gene proportion as gene age increases.
View Article and Find Full Text PDFT cells are a type of white blood cell that play a critical role in the immune response against foreign pathogens through a process called T Cell Adaptive Immunity (TCAI). However, the evolution of the genes and nucleotide sequences involved in TCAI is not well understood. To investigate this, we performed comparative studies of gene annotations and genome assemblies of 28 vertebrate species and identified sets of human genes that are involved in TCAI, carcinogenesis, and ageing.
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- Mitochondrially encoded proteins are key players in the process of oxidative phosphorylation and can be affected by adaptations to low oxygen levels at high altitudes.
- Previous research on high-altitude Phrynocephalus lizards indicated positive selection on their mitochondrial genomes, but these studies were limited by outdated evolutionary trees and insufficient species sampling.
- Our re-evaluation, using improved phylogenetic data, found no overall positive selection on mitochondrial genes for high-altitude adaptations, although we did identify positive selection on COX1 in a specific lineage, suggesting different evolutionary pressures when these ancestors moved back to lower altitudes.