Publications by authors named "Jared A Lashway"
Article Synopsis
- Megalin (Lrp2) is a crucial receptor in the kidneys that helps reclaim important proteins like albumin, and its absence affects various cellular processes, including SGLT2 expression.
- Deleting Lrp2 in opossum kidney cells led to a significant drop in SGLT2 levels and altered gene expression linked to metabolism and mitochondrial function, while Lrp2 knockout mice showed better glucose tolerance on high-fat diets.
- Interestingly, male Lrp2 KO mice faced kidney damage from a Western-style diet, whereas female counterparts showed less susceptibility, indicating a complex relationship between megalin, diet, and metabolic health.
