Publications by authors named "Jaqueline Pereira Moura Soares"
Cutaneous melanoma emerges from the malignant transformation of melanocytes and is the most aggressive type of skin cancer. The progression can occur in different stages: radial growth phase (RGP), vertical growth phase (VGP), and metastasis. Reactive oxygen species contribute to all phases of melanomagenesis through the modulation of oncogenic signaling pathways.
View Article and Find Full Text PDFIncreased acute blood flow induced by the aqueous extract of Euterpe oleracea Mart. fruit pulp in rats in vivo is not related to the direct activation of endothelial cells.
Victória Caroline Bottino Pontes Juliana Pereira Tavares de Melo Tavares Tatiana Rosado Rosenstock Domingos Sávio Rodrigues Marcelo Icimoto Yudi Jaqueline Pereira Moura Soares
J Ethnopharmacol
May 2021
Article Synopsis
- Research shows that the açaí fruit (Euterpe oleracea Mart.) has antioxidant, anti-inflammatory, and anti-lipidemic properties, contributing to lower cardiovascular risks.
- The study aims to assess how a viscous extract from açaí pulp affects blood flow in rats and to understand the underlying mechanisms in rat endothelial cells.
- Results indicate that while the açaí extract increases blood flow through nitric oxide production, its vasodilating effects are not directly due to activation of endothelial cells.
Article Synopsis
- Melanoma is a highly aggressive skin cancer linked to high mortality rates, partly due to its ability to spread (metastasize) and elevated reactive oxygen species (ROS) levels, like superoxide anion.
- Nitric oxide synthase (NOS) can become dysfunctional (uncoupled), producing more ROS when there's a lack of its cofactor tetrahydrobiopterin (BH4), which is crucial for its proper function.
- Treating melanoma cells with BH4 restores NOS function, increasing nitric oxide production, reducing harmful ROS, and ultimately leading to decreased cell growth, reduced ability to form tumors, and increased sensitivity to programmed cell death (apoptosis).