Publications by authors named "Jaqueline Derissi Braz Carlton"
Article Synopsis
- Paracoccidioidomycosis (PCM) is a fungal infection caused by Paracoccidioides spp., where adhesins on the fungus interact with host receptors, playing a key role in disease development.
- The study focused on the 14-3-3 adhesin in P. brasiliensis, revealing that silencing this gene altered fungal morphology, virulence, and biofilm formation capabilities in comparative assays with wild type strains.
- Results indicated that while biomass was similar between silenced and wild type strains, the silenced strain showed reduced production of exopolymeric substances and lower expression of crucial adhesin-related genes during biofilm formation, suggesting gene silencing impacts overall biofilm development.
