Publications by authors named "Jaqueline Derissi Braz"
Article Synopsis
- Paracoccidioidomycosis (PCM) is a significant fungal infection prevalent in Latin America, caused by species from the Paracoccidioides genus, which can exist in both mycelial and yeast forms.
- This study utilized quantitative polymerase chain reaction (qPCR) to measure how specific virulence-related genes expressed in these fungal forms change after they interact with alveolar macrophages and fibroblasts.
- Results indicated a notable increase in the expression of several genes, particularly the 14-3-3 gene, suggesting that these genes are upregulated during interactions with host cells, potentially contributing to the fungi's virulence.
Paracoccidioides species are dimorphic fungi that initially infect the lungs but can also spread throughout the body. The spreading infection is most likely due to the formation of a biofilm that makes it difficult for the host to eliminate the infection. Biofilm formation is crucial for the development of infections and confines the pathogen to an extracellular matrix.
View Article and Find Full Text PDFParacoccidioides brasiliensis is the agent of paracoccidioidomycosis, one of the most important systemic fungal diseases in Latin America. This initiates in lung tissue and can subsequently disseminate to other tissues. Clinical manifestations range from localized forms to disseminated disease that can progress to lethality, probably depending on the relationships among the virulence of the fungus, the immune response and the ability to interact with the surface structures and invade epithelial cells and mononuclear cells of the host.
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