Hemodynamics comparison of an hour-long rest and activity state data in a human coronary digital twin.

Although it is well established that hemodynamics can significantly influence the location and progression of cardiovascular disease (CVD), and 3D blood flow metrics are recognized as potential diagnostic indicators of these diseases, the dynamics of these metrics over time and their variation at different activity levels are not well understood. A relevant example is the impact of exercise on the vascular system over extended periods. Although exercise is widely recognized as a preventive measure of heart disease, the specifics of how activity levels and subsequent alterations in blood flow contribute to the mechanisms that drive CVD remain unclear.