Macronutrient intake: Hormonal controls, pathological states, and methodological considerations.

A plethora of studies to date has examined the roles of feeding-related peptides in the control of food intake. However, the influence of these peptides on the intake of particular macronutrient constituents of food - carbohydrate, fat, and protein - has not been as extensively addressed in the literature. Here, the roles of several feeding-related peptides in controlling macronutrient intake are reviewed.

Application of series of monoclonal antibodies against human white cell differentiation antigens and the common ALL antigen in the characterization of leukemia cells.

The specificity and the clinical usefulness of the hybridoma derived monoclonal antibodies raised against the differentiation antigens of granulocytes (VIM-D5, VIM-C6), monocytes (VIM-D2), B lymphocytes (VIB-C5, VIC-Y1), erythrocytes (VIE-G4) and CALLA (VIL-A1) was studied in leukemic cells isolated from peripheral blood and bone marrow of 41 adults with acute leukemia by using indirect fluorescence method. The VIL-A1 positivity was observed in 4/9 of ALL and in none of myeloid leukemia. It was accompanied in 3/4 of cases by VIB-C5 positivity and in one case by VIE-G4 positivity.

Seven day cytosine arabinoside administered subcutaneously plus daunorubicin for remission induction in AML.

51 patients (mean age 40, range 17-71) with previously untreated AML (25% of M4-6 FAB type) were given Ara-C subcutaneously 100 mg/m2 every 12 h for 7 days and DNR 45 mg/m2 on days 1-3 i.v. for inducing remission.

[Treatment of acute leukemias in adults. IV. Treatment results on 375 patients at 9 hematology centers].

On the basis of standardized protocols of the therapeutic results of acute non-lymphoblastic leukaemias in adults sent to the Institute of Haematology in Warsaw from 8 haematological centres in Poland it was demonstrated that complete remission occurred in 34.4% of patients (129 out of 375 cases). The mean survival time of the patients treated intensively according to programmes I, II, III and IV 8.

[Terminal DNA nucleotidyltransferase in blastic crisis in myelocytic leukemia].

The importance of determination of the activity of TdT is discussed in the light of a case of chronic myeloid leukaemia in a patient aged 55 years in whom after 4 years from the onset of the disease blastic crisis developed. High TdT activity was correlated with other features of blastic crisis of lymphoid character and with good response to vincristine and prednisone. This enzyme which is a valuable marker of lymphoblasts can predict also blastic crisis and give cues as to proper treatment.

Acid phosphatase activity of the lymphocytes during polychemotherapy of lymphoproliferative diseases.

In 4 adults with malignant lymphoma and in 3 cases of acute lymphoblastic leukemia the acid phosphatase activity in lymphocytes during the consecutive cycles of polychemotherapy was examined paralelly with the estimation of the receptors for sheep erythrocytes. Depression of the enzymatic reaction was observed immediately after the onset of the cytostatic treatment, its normalization between the cycles and after the full remission was reached. A remarkable and lasting decrease of the phosphatase positive lymphocytes and a change in the expression of the enzymatic reaction was noticed in the course of L-asparaginase administration.

Lymphocyte subpopulations bearing different surface markers in non-Hodgkin lymphoma.

Lymphoid cells isolated from peripheral blood and lymph nodes were examined by using the rosette test with sheep erythrocytes (E), the immunofluorescent staining of the surface immunoglobulins (SmIg), the rosette test with mouse C 57 BL erythrocytes (Em and a combined test (SmIg + E). These studies were performed in 143 patients with various subtypes of non-Hodgkin lymphoma and in 110 controls. In the control group the following percentage of cell types was obtained: 1) blood (n = 110): T-68 +/- 12, B- 20 +/- 3, O- 11 +/- 7, BT- 1 +/- 1.

The monitoring of lymphocyte subpopulations in non Hodgkin lymphoma patients during chemotherapy.

Numerous examinations of the changes in B, T, null subpopulations were systematically carried out in 20 non Hodgkin lymphoma patients 8, 24, 48 hours after the therapy onset and subsequently at intervals of a few days during and after each chemotherapy cycle (COP, Knospe). T cells were evaluated by examining the receptor for neuraminidase pretreated sheep erythrocytes (nE), B lymphocytes by detecting surface immunoglobulins (SmIg) with normal and Fc deprived anti Fab2 globulin, moreover receptors for mouse erythrocytes (Em) and for C3 (EAC) were examined. A characteristic rise of the dominating subpopulation was observed during the first phase of the drug application which, most probably, was due to an expulsion of the pathological cells from involved lymphatic organs to the blood.

[Results of immunotherapy of acute leukemias with BCG vaccine of Polish production].

In 18 patients with acute leukaemia complete remission was obtained by chemotherapy and it was tried then to prolong remissions repeating at weekly intervals BCG immunization by the method of searification. In one patient no response was obtained, in 5 cases leukaemic exacerbations occurred after withdrawal of cytostatic agent. Twelve patients were maintained in complete remission during BCG vaccinations for 3.