Thirteen patients with chronic autoimmune thrombocytopenia (AITP) were treated for 14 days with daily oral doses of 120 mg of the novel platelet-activating-factor (PAF) antagonist WEB 2086 BS. Clinical bleeding symptoms remained essentially unchanged in 9 patients and became more pronounced in the post-treatment period in 4 patients. In no case was an increase in platelet counts observed.
View Article and Find Full Text PDF"Haemostasis time" (HT), the occlusion time of a Butterfly 25 short cannula inserted into the cubital vein, is a bleeding time modification comparable to the skin bleeding times according to Duke and Ivy/Mielke. It also measures platelet function and is not influenced more than the latter tests by clotting factors. In HT, subendothelium is replaced by a standard artificial surface.
View Article and Find Full Text PDFThe ultrastructure of the platelet contacts with collagen fibrils (CF) as well as the course taken by CF on the platelet surface were studied on ultrathin sections of platelets and CF. Platelets from normal donors and from a patient with thrombasthenia were incubated in citrated plasma with collagen. For electron microscopy a protein-stabilizing fixation procedure was applied.
View Article and Find Full Text PDFThe occlusion time ("haemostasis time" - HT) of a thin, short cannula inserted into the cubital vein, was compared with the skin bleeding times of the Duke and Ivy/template techniques. 25 male and 25 female volunteers without a history of bleeding were divided into 5 equally large age groups ranging from 10 to over 50 years of age. They exhibited a range of 46 s-6 min 38 s (95% tolerance interval), while the Duke and Ivy/template bleeding times, which were simultaneously determined, corresponded to values given by other authors.
View Article and Find Full Text PDFVirchows Arch A Pathol Anat Histopathol
April 1986
In a case of pancreatic endocrine carcinoma hypercalcaemia without bone metastases and normal parathyroid glands prompted our suspicion that there was paraneoplastic production of an osteoclast activating substance by the tumour tissue. This view was further confirmed by bone histology. Immunohistology post mortem revealed the production of PTH in the primary tumour and a liver metastasis.
View Article and Find Full Text PDFThe so-called nucleated thrombocytes of the domestic fowl (and mallard) were analyzed intravitally by use of phase- and interference-contrast microscopy with regard to their morphology and functional state, and in comparison to other avian blood cells and mammalian blood platelets. Since nucleated thrombocytoid cells of birds do not differ in size from white blood cells, they are automatically included in differential cell counts. They can easily be confused with other white blood cells and even with erythrocyte ghosts, which also appear to be hemostatically active elements.
View Article and Find Full Text PDFBy analyses of electron micrographs it was investigated whether nucleated thrombocytes of chickens described in the literature can be differentiated from lymphoid cells with sufficient certainty as an independent cell system. The result was negative. The mixture of lymphoid cells and so-called thrombocytes investigated was extremely polymorphous and, unlike mammalian platelets, proved to be one cell system containing younger and more mature cells.
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