High concentration of kynurenic acid in bile and pancreatic juice.

Kynurenic acid (KYNA) is an agonist of the G-protein-coupled receptor GPR35, which is predominantly expressed in gastrointestinal tissues. The aim of this study was to determine the content of KYNA in gastric juice, bile and pancreatic juice and intestinal content. KYNA was determined by means of high performance liquid chromatography.

Effect of nimesulide-a preferential COX-2 inhibitor on arterial blood pressure, compared to ketoprofen.

Clinical and experimental studies have shown that renal and cardiovascular effects of most selective COX-2 inhibitors (rofecoxib, celecoxib) are similar to other traditional NSAIDs (dual COX inhibitors). In these study the effect of nimesulide--preferential COX-2 inhibitor, administration on 24-hour blood pressure profile was investigated in 40 adult individuals on antihypertensive therapy with pain states caused by osteoartritis. Nimesulide was administered orally, twice a day at the conventional dose of 0.

Peptic ulcer among rural population in a selected region of south-eastern Poland.

Environmental conditioning of peptic ulcer, territorial variations in the occurrence of this disease, as well as reports indicating changes in the natural history of peptic ulcer provided incentives to undertake the present study. The aim of the study was to determine whether the above-mentioned changes in the course of peptic ulcer also concerned rural population from the agricultural region of south-eastern Poland. The study covered 1,647 patients with peptic ulcer treated in the General Surgery Ward at the Specialist Hospital in Brzozów (Rzeszów Region) between 1980-1999.

Selected socio-economic features and the prevalence of peptic ulcer among Polish rural population.

The aim of the study was to determine the relationship between the prevalence of peptic ulcer and the occurrence of selected socio-economic features among Polish rural population. The study was conducted based on the all- Polish representative study of the state of health of rural population, and covered a group of 6,512 rural inhabitants aged 20-64 -- 3,107 males and 3,405 females selected by two-stage stratified sampling. Peptic ulcer was diagnosed in 348 people in the study (5.