Monitoring of NSAIDs adverse effects based on spontaneous reports from Wrocław regional adverse drug reactions monitoring center.

The mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs) in majority of cases is responsible for adverse reactions of these therapeutic agents. Obtaining post-registration information on adverse drug reactions (ADRs) by means of the Yellow Card System is a significant element in the process of enhancing the safety of pharmacotherapy. The aim of the study was to analyze ADRs of NSAIDs (anti-inflammatory and analgesic drugs) reported to the Regional Centre for the Monitoring of Adverse Drug Reactions (RCMADR) in Wrocław in the years 2007-2009.

[The conductivity of potassium ion channels in lymphocytes T of patients with pollinosis].

Ion channels, as integral membrane protein structures controlling a passive ion transport across cell membranes, contribute importantly to cellular signaling processes. The voltage gated potassium channels Kv1.3 within the membranes of lymphocyte T take part of physiological reactions in these cells.

[Rhinitis and sinusitis: influence on asthma and COPD].

Basing on epidemiology, pathophysiology and clinical manifestations we can show an important correlation between rhinitis and bronchial asthma. Prevalence of allergic rhinitis in childhood is an early manifestation of atopy. It is estimated that allergic rhinitis occurs in about 60% of patients before the onset or simultaneously with bronchial asthma.

[Significance of CYP2D6 oxidation genotype as a risk factor in development of allergic diseases].

The relationship between genetically determined polymorphic metabolism and susceptibility to allergic diseases has aroused much interest. The aim of our study was to evaluate whether patients with allergic diseases, like atopic asthma and allergic rhinitis differ from healthy persons in their CYP2D6 genotype. Study completed 400 persons, 100 patients with allergic diseases--62 with atopic asthma and 38 with allergic rhinitis and 300 healthy volunteers as a control group.

[Histamine receptors expression on lymphocytes and neutrophils in glucocorticosteroid sensitive and resistant asthma patients].

Histamine is a physiological mediator which exerts both, effector and regulatory influence through its receptors on various cells. In the study we evaluated the expression of histamine receptors (HR) on inflammatory cells (lymphocytes and neutrophils) in glucocorticosteroid sensitive (n. = 17) and resistant (n.